Methods in enzymology vol 585: proteomics in biology, Part A

SHUKLA, A K ed
cover image
Publication
USA Elsevier Inc / Academic Press 2017
ISBN
9780128097427
Physical Description
xviii 529p
Series
Methods in Enzymology
URL
Language
eng
 
 
 
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$a One of the powers of proteomics approaches has been the possibility of studying the biological processes at organellar and organism levels. This has opened up the possibilities of obtaining a global and holistic view of biological processes in physiologically relevant context instead of in isolation. A number of chapters in these two volumes cover this aspect, for example, analysis of body fluid degradomics, global assessment of protein synthesis in C. elegans, comprehensive analysis of E. coli membrane proteins, and a few others. These chapters underline the robust platform that proteomics can provide for generating important systems-wide clues in biology. Another important application of proteomics, in addition to being a discovery engine for basic biology, is that it can open up new possibilities in disease etiology and therapeutics, for example, by identifying novel biomarkers or by presenting a comparative proteome-wide view of pathological vs normal tissues.
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Subject
E-BOOKS
ENZYMOLOGY
METHODS AND PROTOCOLS
LIFE SCIENCES
PROTEOMICS
MOLECULAR BIOLOGY
Summary
One of the powers of proteomics approaches has been the possibility of studying the biological processes at organellar and organism levels. This has opened up the possibilities of obtaining a global and holistic view of biological processes in physiologically relevant context instead of in isolation. A number of chapters in these two volumes cover this aspect, for example, analysis of body fluid degradomics, global assessment of protein synthesis in C. elegans, comprehensive analysis of E. coli membrane proteins, and a few others. These chapters underline the robust platform that proteomics can provide for generating important systems-wide clues in biology. Another important application of proteomics, in addition to being a discovery engine for basic biology, is that it can open up new possibilities in disease etiology and therapeutics, for example, by identifying novel biomarkers or by presenting a comparative proteome-wide view of pathological vs normal tissues.