Macromolecular Crystallography Protocols: Volume 2: Structure Determination

DOUBLIE, S ed.
cover image
Publication
Totowa, NJ : Humana Press, 2007.
ISBN
9781588299024 / eISBN:9781597452663
Printed edition: 9781588299024
Physical Description
XII, 284 p. 70 illus. online resource.
Series
Methods in Molecular Biology™ Vol 364
URL
Language
eng
 
 
 
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$a Cryocrystallography of Macromolecules -- Determination of Reaction Intermediate Structures in Heme Proteins -- Annealing Macromolecular Crystals -- First Analysis of Macromolecular Crystals -- X-Ray Data Collection From Macromolecular Crystals -- Characterizing a Crystal From an Initial Native Dataset -- Molecular Replacement -- Phase Determination Using Halide Ions -- The Same But Different -- Substructure Determination in Multiwavelength Anomalous Diffraction, Single Anomalous Diffraction, and Single Isomorphous Replacement With Anomalous Scattering Data Using Shake-and-Bake -- Substructure Determination in Isomorphous Replacement and Anomalous Diffraction Experiments -- Automated Structure Solution With autoSHARP -- to Macromolecular Refinement -- Quality Control and Validation -- Crystallographic Software.
520
$a In the decade since publication of the first edition of Crystallographic Methods and Protocols the field has seen several major developments that have both accelerated the pace of structure determination and made crystallography accessible to a broader range of investigators. Volume I, Preparation and Crystallization of Macromolecules is dedicated to the crystallization and ways to increase the odds of obtaining crystals in macromolecules, while Volume 2, Structure Determination, covers both computational methods for characterizing crystals and solving structures.
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Subject
LIFE SCIENCES
CELL BIOLOGY
METHODS AND PROTOCOLS
E-BOOKS
Summary
In the decade since publication of the first edition of Crystallographic Methods and Protocols the field has seen several major developments that have both accelerated the pace of structure determination and made crystallography accessible to a broader range of investigators. Volume I, Preparation and Crystallization of Macromolecules is dedicated to the crystallization and ways to increase the odds of obtaining crystals in macromolecules, while Volume 2, Structure Determination, covers both computational methods for characterizing crystals and solving structures.
Table of Contents
Cryocrystallography of Macromolecules -- Determination of Reaction Intermediate Structures in Heme Proteins -- Annealing Macromolecular Crystals -- First Analysis of Macromolecular Crystals -- X-Ray Data Collection From Macromolecular Crystals -- Characterizing a Crystal From an Initial Native Dataset -- Molecular Replacement -- Phase Determination Using Halide Ions -- The Same But Different -- Substructure Determination in Multiwavelength Anomalous Diffraction, Single Anomalous Diffraction, and Single Isomorphous Replacement With Anomalous Scattering Data Using Shake-and-Bake -- Substructure Determination in Isomorphous Replacement and Anomalous Diffraction Experiments -- Automated Structure Solution With autoSHARP -- to Macromolecular Refinement -- Quality Control and Validation -- Crystallographic Software.
Notes
Springer Protocols
Methods in Molecular Biology™, 1064-3745 ; 364