Tumor regression and modulation of gene expression via tumor-targeted tocotrienol niosomes

TAN Doryn Meam Yee
Call Number
PR 10772
Added Author
FU Ju Yen
WONG FU Shun
ER Hui Meng
CHEN Yu Sui
KALANITHI Nesaretnam
MPOB IC ; Malaysian Palm Oil Board (MPOB)
Publication
2017
URL
Language
eng
Location Item Class Call Number Accession Number Copy Number Barcode Status eResource  
Special Collection - HQ
Photocopies-Reprints
PR 10772
PR10772
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IN CATALOGING
 
 
 
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vtls000095827
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20171013115100.0
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171012 2017                  000 0 eng d
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$a PR 10772
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$a TAN Doryn Meam Yee
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$a Tumor regression and modulation of gene expression via tumor-targeted tocotrienol niosomes
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$c 2017
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$a FU Ju Yen
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$a Product Development & Advisory Services Division, Malaysian Palm Oil Board, No 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor Darul Ehsan, Malaysia.
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$a In Nanomedicine 2017 Vol 12 (20) October : 2487-2502
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$a INPRO @ Radzuan
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$a Anugerah Penerbitan 2017
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$a Aim: To develop 6-O-palmitoyl-ascorbic acid-based niosomes targeted to transferrin receptor for intravenous administration of tocotrienols (T3) in breast cancer.
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$a Materials & methods: Niosomes were prepared using film hydration and ultrasonication methods. Transferrin was coupled to the surface of niosomes via chemical linker. Nanovesicles were characterized for size, zeta potential, morphology, stability and biological efficacy..
520
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$a Results: When evaluated in MDA-MB-231 cells, entrapment of T3 in niosomes caused 1.5-fold reduction in IC50 value compared with nonformulated T3. In vivo, the average tumor volume of mice treated with tumor-targeted niosomes was 12-fold lower than that of untreated group, accompanied by marked downregulation of three genes involved in metastasis.
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$a Conclusion: Findings suggested that tumor-targeted niosomes served as promising delivery system for T3 in cancer therapy
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$a FU Ju Yen
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$a WONG FU Shun
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$a ER Hui Meng
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$a CHEN Yu Sui
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$a KALANITHI Nesaretnam
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$u https://doi.org/10.2217/nnm-2017-0182
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Subject
Subject
Summary
Aim: To develop 6-O-palmitoyl-ascorbic acid-based niosomes targeted to transferrin receptor for intravenous administration of tocotrienols (T3) in breast cancer.
Materials & methods: Niosomes were prepared using film hydration and ultrasonication methods. Transferrin was coupled to the surface of niosomes via chemical linker. Nanovesicles were characterized for size, zeta potential, morphology, stability and biological efficacy..
Results: When evaluated in MDA-MB-231 cells, entrapment of T3 in niosomes caused 1.5-fold reduction in IC50 value compared with nonformulated T3. In vivo, the average tumor volume of mice treated with tumor-targeted niosomes was 12-fold lower than that of untreated group, accompanied by marked downregulation of three genes involved in metastasis.
Conclusion: Findings suggested that tumor-targeted niosomes served as promising delivery system for T3 in cancer therapy
Corresp. Author
FU Ju Yen
Product Development & Advisory Services Division, Malaysian Palm Oil Board, No 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor Darul Ehsan, Malaysia.
Notes
In Nanomedicine 2017 Vol 12 (20) October : 2487-2502
INPRO @ Radzuan
Anugerah Penerbitan 2017